Viagra is considered to be one of the most effective drug when it comes to erectile dysfunction
Though the medicine comes with various trade names, it is a medicine chemically composed of Sildenafil citrate is considered to be one of the most effective drug when it comes to erectile dysfunction. Primarily, the drug works by inhibiting the enzyme involved in the regulation of the blood in and out of the blood sinuses of the penis. Initially, being investigated for its effects in high blood pressure and ischemic heart disease, the cGMP specific phospgodiesterase enzyme inhibitor was found to be causing significant penile erection. After discovering that, the chemists at Pfizer’s Sandwich, UK modified the substance to be used as a remedy for erectile dysfunction.
The drug was so much successful that it became the first one of its kind to treat the erectile disorder of men.
The primary target dictating the effectiveness of the medicine is the rapid increase of blood flow to corpus cavernosum of the penis. This is brought about by the raised levels of cGMP, a nucleotide, that relaxes the smooth muscles of the blood vessels lining the corpus cavernosum. cGMP level in turn is exaggerated by the combination of nitric oxide and guanylate cyclase. NO, being the key component, is released by sildenafil citerate. Relaxation and thus the increased blood flow through the blood vessels leads o fpenis finally leads to the satisfactory erection of the penis for the sexual intercourse.
Being an important remedy of a serious sexual problem, sildenafil citerate offers cure for many other diseases of the body such as in pulmonary arterial hypertension, right sided heart failure and high altitude respiratory edema, thus proving its importance in the treatment of respiratory tract.